Oral cyclic peptide platform: As a peptide drug composed of amino acids, cyclic peptides have minimal toxic side effects and meet the long-term needs of chronic disease patients; Cyclic peptides have higher stability than linear peptides and are not easily hydrolyzed by proteases in the human body. They are easy to make into oral preparations, improve patient compliance, and break the limitations of most peptide drugs that can only be administered by injection.
Synthetic lethal platform: refers to the existence of two partner genes A and B. When one gene A mutates or cannot function, the cell can still survive. However, when an inhibitor of gene B is used to render gene B ineffective, it can lead to cell death. Tumor cells often have a large number of mutations and gene replication errors, which are not present in normal cells. If tumor mutation genes and corresponding synthetic lethal pairing genes are found and targeted, it is possible to "precisely kill" tumor cells containing specific mutations without affecting the expression of normal cellular physiological functions.
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